Anti-Diabetic and Anti-Oxidative Effect of Aloe Vera (L.) Gel: An In- Vitro Approach

Abstract

Medicinal plants are utilized in various formulations to treat a wide range of illnesses, includig diabetes.The present study focused on anti-diabetic and anti-oxidative effect of Aloe vera (L.) in an in-vitro model. Wistar strain albino rats with less than 350 mg/dl of fasting blood glucose level on the 7th day of Streptozotocin (STZ) injection were considered for this study and left for obverting a chronic state of diabetes. On the 29th day of STZ injection, rats were sacrificed and targeted tissues were incubated for 2 hours in an in-vitro medium with 1, 2, and 4 mg of Aloe vera (L.) hydro-ethanol (40:60) extract (AVHE) separately and subjected to evaluation with adopted parameters. Results showed a significant (p˂0.05) recovery in the glucose-6- phosphatase and oxidative stress markers along with GOT and GPT activities in extract-charged groups whereas no significant (p>0.05) changes was noted in hexokinase enzymes activity compared to the unexposed diabetic group. Statistical analysis showed no significant (p>0.05) difference in the recovery level among 1, 2, and 4 mg doses of AVHE. It can be concluded that AVHE has direct ameliorative effect on diabetes and its linked oxidative stress markers.