Management of Bisphenol-A Induced Hepato-Renal Disorder in Wistar Rat by Wheatgrass Aqueous Extract Co-Administration

Abstract

Bisphenol-A (or BPA) is a renowned endocrine disruptor in current use. This study concentrated on the restorative effects of wheatgrass methanolic extract (WG-ME) on the liver and kidney in rats treated with BPA. For this purpose, 18 Wistar rats were divided into 3 groups: Control; BPA (100mg/kg); BPA+ WG-ME (100 mg/kg BPA + 200mg/kg WG-ME) by oral gavage for 28 days study period. Dissected liver and kidney were procured and stored at -20oC for the evaluation of cellular antioxidant status. For the analysis of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea and creatinine levels, which have a role in measuring liver and kidney toxicity, blood samples were collected. In parallel, BPA decreases cellular antioxidant levels super-di-oxide (SOD), catalase and GPx in liver and kidney. The hepato-renal functional tests and antioxidant enzyme levels were significantly improved with the addition of WG-ME oral consumption. These findings provided that protective effect of WG-ME improving BPA-induced metabolic alterations.