Ameliorating Efficacy of Riboflavin in Arsenic Induced Cytotoxicity in the Liver of Swiss Albino Mice

Abstract

Arsenic has been found to cause severe cytological alterations in animal hepatic tissues. Oxidative stress induced by arsenic produces reactive oxygen intermediates. Present study aims to explore the extent of damage caused by sub lethal dose of arsenic, and to monitor the biochemical, cytological and histopathological changes caused by the toxic heavy metal. High levels of stress enzymes like phosphatase, peroxidase were noted in the liver. Down regulation of antioxidant enzymes like, peroxidase, dismutase, and catalase were noted in arsenic infected liver. Overall protein metabolism was affected due to arsenic induced cytotoxicity. Present study indicates abnormalities in all such cellular proteins and enzymes. The results also indicate the efficacy of riboflavin in combating arsenic induced cytotoxicity in liver to reduce oxidative stress caused by arsenic in the vitalorgans.