Recovery effects of Zinc-Oxide and fructooligosaccharides nano conjugate on nicotine-induced oxidative stress on cardiac tissue in adult albino rat

Abstract

Nicotine is major toxic component of tobacco products which are capable of producing free radicals and causes oxidative stress. Zinc and Fructooligosaccharides (one type of soluble dietary fiber) both are good for cardiac health as a dietary supplement (which is digested by gut bacteria). Both have a good and significant role on cardiac health. Our main objectives of this study to prepared a new nanoconjugate and apply against nicotine induced cardiac toxicity for recovery. In this study we prepared a nano-conjugate compound with zincoxide and Fructooligosaccharides (ZnO-FNC) by chemical synthesis method and characterized by using SEM and FTIR analysis. We apply ZnO-FNC on nicotine induced albino rat and measured SOD, LPO, CAT level of heart tissue and serum LDH level. Results shows that ZnO-FNC help to reduce oxidative stress of heart tissue induced by nicotine and all the data were changed significantly (P < 0.05) compare to nicotine treated group and closed to the control group. ZnO-FNC has potential effects on oxidative damage and it is a new approach of nutritional therapy against cardiac stress.