EFFECT OF ASPHYXIA ON BLOOD PRESSURE AND URINE FLOW IN NICOTINIZED ANIMALS: ROLE OF SYMPATHETIC ADRENOCEPTORS

Abstract

In the present study attempts have been made to study the combined effects of experimentally induced asphyxia and nicotine alterations in cardio-renal functions of cat. At the same time attempts have been made to find out the possible sympathetic adrenoceptors involvement in asphyxia along with nicotineinduced alterations in hypertension as well as urine flow. It was noted from the results that asphyxia caused hypertension associated with changes in urine flow (antidiuresis and diuresis). These cardio-renal changes were significantly more profound in case of asphyxia along with the nicotine. Pretreatments with specific sympathetic blocker, asphyxiated and asphyxia with nicotinized animals, failed to elicit any alterations in blood pressure; but at the same time antidiuresis and diuresis were partially counteracted in such animals. It may be concluded that catecholamines released by asphyxia and nicotine may cause initial rise in blood pressure along with antidiuresis, which are the effect of á adrenoceptors involvement. Subsequent diuresis during falling phase of blood pressure is not related with α adrenoceptors. The role of α adrenoceptors is greater during asphyxia along with nicotinized condition in comparison to asphyxia alone.